Recombinant Rabbit Interleukin 6 receptor (IL6R), partial, Oryctolagus cuniculus (Rabbit), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 41.9kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Rabbit Interleukin 6 receptor (IL6R), partial

Recombinant Rabbit Interleukin 6 receptor (IL6R), partial — Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. Purity >90%.

SKU: BCRECP-003172 Categories: ,
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Product Specifications

Product SkuBCRECP-003172
Product DescriptionRecombinant Rabbit Interleukin 6 receptor (IL6R) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 76-385aa. [Accession | G1TBG5].
Uniprot No.G1TBG5
Gene NamesIL6R
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region76-385aa
SpeciesOryctolagus cuniculus (Rabbit)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight41.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Secreted

Product Specifications

Recombinant Rabbit Interleukin 6 receptor (IL6R), partial is a recombinant protein from Oryctolagus cuniculus (Rabbit), expressed in E.coli, covering amino acids 76-385aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 41.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production. Plays a protective role during liver injury, being required for maintenance of tissue regeneration. 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Secreted

Subunit

Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6 to associate with the signaling subunit IL6ST. Interacts (via N-terminal ectodomain) with SORL1; this interaction may affect IL6-binding to IL6R, hence decrease IL6 'classic-signaling'

Gene: IL6R  |  Organism: Oryctolagus cuniculus  |  Synonyms: IL-6R 1

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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