High-Purity CD Proteins
BioCrest Sci provides 280 high-purity recombinant CD (cluster of differentiation) proteins — CD3, CD19, CD20, CD28, CD37, CD47 and more — for immunophenotyping, cell biology, and therapeutic antibody development. Purity greater than 90%.
What Are CD Proteins?
CD (cluster of differentiation) proteins are cell-surface molecules used to identify and classify leukocytes via monoclonal antibodies. Established through the Human Leukocyte Differentiation Antigens (HLDA) workshops, the CD nomenclature now spans over 370 antigens — making CD proteins the lingua franca of immunology.
Key CD Proteins by Function
T Cell Markers: CD3, CD4, CD8, CD28
CD3 defines the TCR complex; CD4 and CD8 mark helper and cytotoxic T cells; CD28 is the prototypic co-stimulatory receptor. Recombinant CD proteins enable tetramer preparation, antibody validation, and functional T cell assays.
B Cell and Hematologic Targets: CD19, CD20, CD22, CD37, CD38
The most successful therapeutic target cluster: rituximab (CD20), blinatumomab (CD19), daratumumab (CD38), and CAR-T therapies (CD19, CD22, BCMA) all target CD antigens. Recombinant CD proteins are essential for drug development and bioanalytical assays.
Myeloid Markers: CD11b, CD14, CD33, CD68
Define monocyte/macrophage populations in flow cytometry; CD33 and CD47 are active drug targets (gemtuzumab ozogamicin, magrolimab).
Applications
- Flow cytometry antibody validation and compensation
- CAR-T target antigen supply and bioassay development
- Therapeutic antibody binding and SPR studies
- Cell sorting and immunophenotyping reagents
Explore the complete CD Proteins collection or contact sales@biocrestsci.com.