Mouse anti-Human/Mouse/Rat sapiens (Human) CREB1 Monoclonal Antibody

Function

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity)

Subcellular Location

Nucleus

Disease Association

Angiomatoid fibrous histiocytoma (AFH) : A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. [The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type] | [A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to surfactant, thymus hypoplasia, and thyroid follicular hypoplasia]

Subunit

(Microbial infection) Interacts with HTLV-1 protein Tax

• Berkowitz L.A. et al. Two distinct forms of active transcription factor CREB (cAMP response element binding protein). — Proc. Natl. Acad. Sci. U.S.A. (1990)
• Yoshimura T. et al. Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. — EMBO J. (1990)
• Waeber G. et al. Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing. — Trans. Assoc. Am. Physicians (1990)
• Hoeffler J.P. et al. Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. — Science (1988)
• Short M.L. et al. Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells. — Nucleic Acids Res. (1991)
• Huang X. et al. Cloning and expression of a novel CREB mRNA splice variant in human testis. — Reproduction (2004)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Meyer T.E. et al. The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription. — Endocrinology (1993)