Mouse anti-Human sapiens (Human) CALCOCO2 Monoclonal Antibody
Mouse anti-Human sapiens (Human) CALCOCO2 Monoclonal Antibody - Image 2
Mouse anti-Human sapiens (Human) CALCOCO2 Monoclonal Antibody - Image 3

Mouse anti-Human sapiens (Human) CALCOCO2 Monoclonal Antibody

Mouse anti-Human sapiens (Human) CALCOCO2 Monoclonal Antibody — Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation.

SKU: BCREC-000943MA Category:
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Product Specifications

Uniprot No.Q13137
Target NamesCALCOCO2
Species ReactivityMouse
ImmunogenRecombinant Human CALCOCO2 protein
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeMouse IgG1
ClonalityMonoclonal
ApplicationsELISA, WB, FC, ICC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation.

Biological Context

Subcellular Location: Cytoplasm, perinuclear region; Cytoplasm, cytoskeleton; Cytoplasmic vesicle, autophagosome membrane (Peripheral membrane protein)
Tissue Specificity: Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain

Product Specifications

Mouse anti-Human sapiens (Human) CALCOCO2 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994)

Subcellular Location

Cytoplasm, perinuclear region; Cytoplasm, cytoskeleton; Cytoplasmic vesicle, autophagosome membrane (Peripheral membrane protein)

Tissue Specificity

Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain

Subunit

(Microbial infection) Interacts with Mopeia virus protein Z

Gene: CALCOCO2  |  Organism: Homo sapiens  |  Synonyms: Antigen nuclear dot 52 kDa protein; Nuclear domain 10 protein NDP52; Nuclear dot protein 52
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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