Recombinant Macaca mulatta Interleukin-6 receptor subunit alpha (IL6R), Partial (Active), Macaca mulatta (Rhesus macaque), Mammalian cell, C-terminal 10xHis-tagged, 39.5 kDa, purity >95% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.
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Recombinant Macaca mulatta Interleukin-6 receptor subunit alpha (IL6R), Partial (Active)

Recombinant Macaca mulatta Interleukin-6 receptor subunit alpha (IL6R), Partial (Active) — Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. Purity >95%.

SKU: BCACP-000513 Categories: ,
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Product SKUBCACP-000513
Product DescriptionRecombinant Rhesus macaque Interleukin-6 receptor subunit alpha (IL6R), Partial protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 20-365aa. [Accession | A0A5F8AUE5].
Uniprot No.A0A5F8AUE5
Gene NamesIL6R
PurityGreater than 95% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region20-365aa
SpeciesMacaca mulatta (Rhesus macaque)
Tag InfoC-terminal 10xHis-tagged
Molecular weight39.5 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human CSF3R at 2 μg/mL can bind Human CSF3 ). The EC50 is 33.76-58.81 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Human CSF3R at 2 μg/mL can bind Anti-CSF3R recombinant antibody . The EC50 is 2.544-2.926 ng/mL.;Human CSF3 ) captured on Protein A Chip can bind Recombinant Human CSF3R with an affinity constant of 0.123 nM as detected by MetaSPR Assay (WeSPRTM 200).;CSF3R Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Human CSF3R with an affinity constant of 0.157 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInterleukin-6 receptor subunit alpha; IL-6R 1

Function

Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases.

Product Specifications

Recombinant Macaca mulatta Interleukin-6 receptor subunit alpha (IL6R), Partial (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 20-365aa, with C-terminal 10xHis-tagged tag, molecular weight 39.5 kDa, purity Greater than 95% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production. Plays a protective role during liver injury, being required for maintenance of tissue regeneration. 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis

Gene: IL6R  |  Organism: Macaca mulatta

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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