Recombinant Human Bone morphogenetic protein 7 (BMP7)，Partial (Active), Homo sapiens (Human), Mammalian cell, Tag free, 13.1 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Bone morphogenetic protein 7 (BMP7)，Partial (Active)

Recombinant Human Bone morphogenetic protein 7 (BMP7)，Partial (Active) — Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Purity >95%.

SKU: BCACP-001118 Category:
Online Inquiry →
Product SKUBCACP-001118
Product DescriptionRecombinant Human Bone morphogenetic protein 7 (BMP7)，Partial protein is expressed from Mammalian cell with Tag free. It contains M+316-431aa. [Accession | P18075].
Uniprot No.P18075
Gene NamesBMP-7
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression RegionM+316-431aa
SpeciesHomo sapiens (Human)
Tag InfoTag free
Molecular weight13.1 kDa
ActivityMeasured in a cell proliferation assay using NIH3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.25-1 ng/mL
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesBone morphogenetic protein 7; BMP-7; Osteogenic protein 1 (OP-1); Eptotermin alfa; BMP7; OP1

Function

Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed in the kidney and bladder. Lower levels seen in the brain

Product Specifications

Recombinant Human Bone morphogenetic protein 7 (BMP7)，Partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids M+316-431aa, with Tag free tag, molecular weight 13.1 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:12667445, PubMed:9748228). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509)

Subcellular Location

Secreted

Tissue Specificity

Expressed in the kidney and bladder. Lower levels seen in the brain

Subunit

Homodimer; disulfide-linked (PubMed:8570652). Interacts with SOSTDC1 (PubMed:15020244). Interacts with TWSG1 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631). Interacts with type I receptor ACVR1 (PubMed:9748228). Interacts with type II receptor ACVR2A (PubMed:12667445). Interacts with NOG; this interaction inhibits canonical BMP signaling (PubMed:12478285). Interacts with SCUBE3 (PubMed:33308444). Interacts with ERFE; the interaction inhibits BMP-induced transcription of HAMP (PubMed:30097509). Interacts with TGFBR3 (By similarity)

Gene: BMP7  |  Organism: Homo sapiens  |  Synonyms: Osteogenic protein 1
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

Shopping Cart
Scroll to Top