Cytokines, Chemokines & Growth Factors for Life Science Research
BioCrest Sci offers 750+ high-purity recombinant cytokines, chemokines, and growth factors to support immunology, oncology, stem cell, and drug discovery research. Our portfolio covers all major families — interleukins, interferons, TNF superfamily, chemokines (CCL/CXCL), and growth factors (EGF, FGF, VEGF, TGF-β) — with purity greater than 90% verified by SDS-PAGE.
What Are Cytokines?
Cytokines are small secreted signaling proteins that mediate cell-to-cell communication in the immune system. They regulate immune cell growth, differentiation, activation, and migration through specific cell-surface receptors. Cytokines include several subfamilies:
- Interleukins (ILs) — 325+ proteins including IL-1, IL-2, IL-6, IL-10, IL-12, IL-17 families, essential for T cell, B cell, and NK cell research
- Interferons (IFNs) — IFN-α, IFN-β, IFN-γ, and IFN-λ for antiviral immunity and immuno-oncology studies
- TNF Superfamily — TNF-α, TRAIL, RANKL, and receptors for apoptosis, inflammation, and immune checkpoint research
What Are Chemokines?
Chemokines are a specialized cytokine subfamily defined by their chemotactic function — they direct leukocyte migration along concentration gradients. Chemokines are classified by conserved cysteine motifs:
- CC Chemokines (CCL1–CCL28) — attract monocytes, lymphocytes, and eosinophils; key players in inflammation and tumor microenvironment research
- CXC Chemokines (CXCL1–CXCL17) — recruit neutrophils and lymphocytes; CXCL8 (IL-8) and CXCL12 (SDF-1) are heavily studied in cancer metastasis
- Other subfamilies — XC (XCL1/XCL2) and CX3C (CX3CL1/fractalkine) chemokines
Browse our Chemokines collection — 180+ recombinant chemokines for cell migration assays, receptor binding studies, and drug screening.
What Are Growth Factors?
Growth factors are signaling proteins that stimulate cell proliferation, differentiation, and survival. They are essential reagents for cell culture, stem cell biology, organoid research, and regenerative medicine:
- EGF Family — EGF, TGF-α, HB-EGF for epithelial cell culture and cancer research
- FGF Family — FGF-1, FGF-2 (bFGF), FGF-7, FGF-21 for stem cell maintenance and differentiation
- VEGF Family — VEGF-A, VEGF-C, PlGF for angiogenesis and vascular biology research
- IGF Family — IGF-1, IGF-2, insulin for metabolism and cell growth studies
- TGF-β Superfamily — TGF-β1/2/3, BMPs, activins for development and cancer research
- Neurotrophins — NGF, BDNF, NT-3, NT-4 for neuroscience research
Explore our Growth Factors collection — 250+ recombinant growth factors in multiple tag formats.
Applications in Research & Drug Development
- Immuno-oncology: IL-2, IL-15, and IL-12 for T cell and NK cell expansion in adoptive cell therapy
- Autoimmune disease: IL-17, IL-23, and TNF-α as drug targets and assay standards
- Stem cell culture: FGF-2, EGF, and LIF for pluripotent stem cell maintenance
- Vaccine development: Cytokine profiling and adjuvant research
- Cell migration assays: Chemokines for transwell migration and chemotaxis studies
Why Choose BioCrest Sci
- High purity: Greater than 90% purity by SDS-PAGE with low endotoxin levels
- Bioactivity validated: Cell-based activity assays available for active proteins
- Multiple expression systems: E.coli, yeast, insect, and mammalian systems
- Flexible formats: His-tag, Fc-tag, tag-free, lyophilized or liquid
- Fast delivery: Same-day shipping for orders before 2 PM EST
Need help selecting the right cytokine for your assay? Contact our technical support team at sales@biocrestsci.com for expert guidance.