High-Purity Interferons (IFNs)
BioCrest Sci provides 87 high-purity recombinant interferons — IFN-α, IFN-β, IFN-γ, IFN-λ, and their receptors — for antiviral immunity, autoimmune disease, and cancer immunotherapy research. Purity greater than 90%.
What Are Interferons?
Interferons (IFNs) are cytokines named for their ability to “interfere” with viral replication. They are classified into three types: Type I (IFN-α, IFN-β), Type II (IFN-γ), and Type III (IFN-λ), each signaling through distinct receptor complexes to activate JAK-STAT pathways and hundreds of interferon-stimulated genes (ISGs).
Types and Research Applications
Type I: IFN-α and IFN-β
Produced by virtually all cells upon viral infection, Type I IFNs orchestrate antiviral defense and link innate to adaptive immunity. IFN-α remains a therapeutic for hepatitis B/C and melanoma; IFN-β is first-line for multiple sclerosis. Recombinant IFN-α/β are core reagents in antiviral assays, ISG profiling, and autoimmune disease models (lupus, SLE).
Type II: IFN-γ
Secreted by activated T cells and NK cells, IFN-γ is the master Th1 cytokine — activating macrophages, upregulating MHC, and driving anti-tumor immunity. It is the gold-standard readout in ELISpot and intracellular cytokine staining assays.
Type III: IFN-λ
IFN-λs signal through a receptor restricted to epithelial cells, providing mucosal antiviral defense with fewer systemic side effects — making them attractive therapeutic candidates for respiratory viral infections.
Why Choose BioCrest Sci Interferons
- 87 interferons and receptors covering all three types
- Purity greater than 90% with low endotoxin
- Active proteins with verified ED50 values
- Multiple species: human, mouse, rat, and more
Explore the complete Interferon collection or contact sales@biocrestsci.com.