High-Purity VLP Transmembrane Proteins
BioCrest Sci provides 111 high-purity virus-like particle (VLP) transmembrane proteins for antibody screening, immunization, and drug discovery. VLPs display membrane proteins in their native trimeric conformation — ideal for challenging multi-pass targets like GPCRs and ion channels.
What Are VLP Transmembrane Proteins?
Virus-like particles (VLPs) are self-assembling nanoparticle scaffolds derived from viral structural proteins. When a membrane protein is fused to a VLP scaffold, the target is displayed on the particle surface in its native lipid bilayer environment — preserving conformation, topology, and epitopes that are lost in detergent-solubilized or truncated forms.
Why VLP Display Matters for Difficult Targets
Multi-pass transmembrane proteins — GPCRs, ion channels, transporters — are notoriously unstable outside the membrane. VLP display solves the three core problems:
- Native conformation: proteins remain embedded in lipid bilayers, preserving functional structure
- High antigen density: particles display hundreds of copies, boosting immunogenicity
- Stability without detergent: eliminates detergent interference in downstream assays
Applications
- Antibody screening: phage display and hybridoma screening against native epitopes
- Immunization: raising antibodies against conformational epitopes of GPCRs and ion channels
- Drug discovery: target validation and binder identification for antibody therapeutics
- Serology: detecting antibodies against viral envelope proteins
Why Choose BioCrest Sci VLP Proteins
- 111 VLP-displayed transmembrane proteins covering GPCRs, ion channels, and immune targets
- Greater than 90% purity by SDS-PAGE
- Consistent particle size verified by DLS
- Detergent-free formulations for assay compatibility
Explore the complete VLP Transmembrane Proteins collection or contact sales@biocrestsci.com for custom VLP production.