Function
Unknown. Cellular response protein to viral infection.
Biological Context
Subcellular Location: Golgi apparatus, cis-Golgi network membrane (Single-pass type II membrane protein)
Tissue Specificity: Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes
Product Specifications
Recombinant Human Golgi membrane protein 1 (GOLM1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 36-401aa, with N-terminal 6xHis-tagged tag, molecular weight 45.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
