Recombinant Human Keratin, type I cytoskeletal 13 (KRT13), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 57.0kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Keratin, type I cytoskeletal 13 (KRT13)

Recombinant Human Keratin, type I cytoskeletal 13 (KRT13) — Structural component of intermediate filaments in mucosal stratified squamous epithelia. Purity >90%.

SKU: BCRECP-001025 Category:
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Product Specifications

Product SkuBCRECP-001025
Product DescriptionRecombinant Human Keratin, type I cytoskeletal 13 (KRT13) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-458aa. [Accession | P13646].
Uniprot No.P13646
Gene NamesKRT13
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-458aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight57.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type II keratin KRT4, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium. Contributes to postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially through regulation of the G1/S phase cyclins CCNE1 and CCNE2.

Biological Context

Tissue Specificity: Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta
Disease Association: White sponge nevus 2 (WSN2) : A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Keratin, type I cytoskeletal 13 (KRT13) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-458aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 57.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type II keratin KRT4, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium (PubMed:7493031). Contributes to postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially through regulation of the G1/S phase cyclins CCNE1 and CCNE2 (By similarity)

Disease Association

White sponge nevus 2 (WSN2) : A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta

Subunit

Heterodimers composed of one type I and one type II keratins; forms parallel coiled-coil heterodimers. Heterodimers associate in an antiparallel manner to form heterotetramers, which further assemble into higher-order keratin intermediate filaments

Gene: KRT13  |  Organism: Homo sapiens  |  Synonyms: Cytokeratin-13; Keratin-13
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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