Recombinant Human Ribonucleoside-diphosphate reductase large subunit (RRM1), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 92.1kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Ribonucleoside-diphosphate reductase large subunit (RRM1)

Recombinant Human Ribonucleoside-diphosphate reductase large subunit (RRM1) — Provides the precursors necessary for DNA synthesis. Purity >90%.

SKU: BCRECP-001567 Categories: ,
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Product Specifications

Product SkuBCRECP-001567
Product DescriptionRecombinant Human Ribonucleoside-diphosphate reductase large subunit (RRM1) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 1-792aa. [Accession | P23921].
Uniprot No.P23921
Gene NamesRRM1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-792aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight92.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Biological Context

Subcellular Location: Cytoplasm
Disease Association: Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 6 (PEOB6) : A form of progressive external ophthalmoplegia, a mitochondrial myopathy characterized by progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged red fibers are seen on muscle biopsy. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Ribonucleoside-diphosphate reductase large subunit (RRM1) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-792aa, with N-terminal 6xHis-tagged tag, molecular weight 92.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

Subcellular Location

Cytoplasm

Disease Association

Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 6 (PEOB6) : A form of progressive external ophthalmoplegia, a mitochondrial myopathy characterized by progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged red fibers are seen on muscle biopsy. [The disease may be caused by variants affecting the gene represented in this entry]

Subunit

Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B. Interacts with AHCYL1 which inhibits its activity

Gene: RRM1  |  Organism: Homo sapiens  |  Synonyms: Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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