Recombinant Human Single Ig IL-1-related receptor(SIGIRR), partial, Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 14.6kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Single Ig IL-1-related receptor(SIGIRR), partial

Recombinant Human Single Ig IL-1-related receptor(SIGIRR), partial — Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Purity >95%.

SKU: BCRECP-001632 Categories: ,
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Product Specifications

Product SkuBCRECP-001632
Product DescriptionRecombinant Human Single Ig IL-1-related receptor(SIGIRR) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 1-118aa. [Accession | Q6IA17].
Uniprot No.Q6IA17
Gene NamesSIGIRR
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-118aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight14.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Biological Context

Subcellular Location: Membrane (Single-pass type III membrane protein)
Tissue Specificity: Mainly expressed in epithelial tissues such as kidney, lung and gut

Product Specifications

Recombinant Human Single Ig IL-1-related receptor(SIGIRR), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-118aa, with N-terminal 6xHis-tagged tag, molecular weight 14.6kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP

Subcellular Location

Membrane (Single-pass type III membrane protein)

Tissue Specificity

Mainly expressed in epithelial tissues such as kidney, lung and gut

Subunit

Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3

Gene: SIGIRR  |  Organism: Homo sapiens  |  Synonyms: Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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