Function
Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis.
Biological Context
Subcellular Location: Membrane (Single-pass type I membrane protein)
Tissue Specificity: High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells
Disease Association: Hyperferritinemia (HRFT) : An autosomal recessive condition characterized by increased serum ferritin levels in the absence of iron overload or other clinical symptoms. [The disease may be caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Stabilin-1 (STAB1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2319-2462aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 22.7kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
