Recombinant Human Telomerase protein component 1 (TEP1), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 28.8kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Telomerase protein component 1 (TEP1), partial

Recombinant Human Telomerase protein component 1 (TEP1), partial — Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Purity >90%.

SKU: BCRECP-001756 Category:
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Product Specifications

Product SkuBCRECP-001756
Product DescriptionRecombinant Human Telomerase protein component 1 (TEP1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 2-226aa. [Accession | Q99973].
Uniprot No.Q99973
Gene NamesTEP1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-226aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight28.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle.

Biological Context

Subcellular Location: Nucleus; Chromosome, telomere
Tissue Specificity: Ubiquitous

Product Specifications

Recombinant Human Telomerase protein component 1 (TEP1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-226aa, with N-terminal 6xHis-tagged tag, molecular weight 28.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity)

Subcellular Location

Nucleus; Chromosome, telomere

Tissue Specificity

Ubiquitous

Subunit

Associates with MVP to form part of the vault particle (By similarity). The vault is a massive cage-like structure; it consists of a dimer of half-vaults, with each half-vault comprising 39 identical MVP subunits (By similarity). The two half-vaults assemble to form the complete vault, where minor vault components such as PARP4, TEP1 and vault RNAs (vRNAs) may bind to the interior (By similarity). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs (By similarity)

Gene: TEP1  |  Organism: Homo sapiens  |  Synonyms: Telomerase-associated protein 1; p240; p80 telomerase homolog
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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