Recombinant Human Tomoregulin-1 (TMEFF1), partial, Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 38.5kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Tomoregulin-1 (TMEFF1), partial

Recombinant Human Tomoregulin-1 (TMEFF1), partial — Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry. Purity >85%.

SKU: BCRECP-001781 Category:
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Product Specifications

Product SkuBCRECP-001781
Product DescriptionRecombinant Human Tomoregulin-1 (TMEFF1) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 40-330aa. [Accession | Q8IYR6].
Uniprot No.Q8IYR6
Gene NamesTMEFF1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region40-330aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight38.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry. Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent. Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues
Disease Association: [Encephalopathy, acute, infection-induced, herpes-specific (IIAE). A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Disease susceptibility is associated with variants affecting the gene represented in this entry ]

Product Specifications

Recombinant Human Tomoregulin-1 (TMEFF1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 40-330aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 38.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry (PubMed:39048823, PubMed:39048830). Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent (PubMed:39048823). Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane (PubMed:39048823, PubMed:39048830). Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors (PubMed:39048823). May be a tumor suppressor in brain cancers (PubMed:12743596)

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Disease Association

[Encephalopathy, acute, infection-induced, herpes-specific (IIAE) (PubMed:39048830). A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals (PubMed:39048830). It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes (PubMed:39048830). Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome (PubMed:39048830). Disease susceptibility is associated with variants affecting the gene represented in this entry (PubMed:39048830)]

Tissue Specificity

Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle (PubMed:12743596). Down-regulated in brain tumors as compared to control brain tissues (PubMed:12743596)

Subunit

May interact with ST14

Gene: TMEFF1  |  Organism: Homo sapiens  |  Synonyms: H7365; Transmembrane protein with EGF-like and one follistatin-like domain
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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