Recombinant Mouse Anti-Muellerian hormone (Amh), partial

Function

Plays an important role in several reproductive functions, including Muellerian duct regression during male fetal sexua,l differentiation and in the adult plays a role in Leydig cell differentiation and function (PubMed:1782869, PubMed:9435237). In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:11606457, PubMed:11861535). Binds to its sole type II receptor, AMHR2 that recruits type I receptors ACVR1 and BMPR1A which subsequently activates the Smad pathway (By similarity)

Subcellular Location

Secreted

Tissue Specificity

Expressed in Sertoli cells of fetal testes, and in testes just after birth, but absent in adult testes. In female, AMH is expressed after birth in the granulosa cells of the follicle

Subunit

Homodimer; disulfide-linked (By similarity). Anti-Muellerian hormone (AMH) is secreted as part of a non-covalent heterotetrameric complex consisting of AMH prodomain and anti-Muellerian hormone homodimers (By similarity). After proteolytic processing, the dimeric AMH prodomain remains non-covalently associated with the active homodimeric anti-Muellerian hormone, amplifying its biological activity (By similarity). The AMH prodomain homodimer is displaced upon binding of anti-Muellerian hormone to its receptor (By similarity)

• Muensterberg A. et al. Expression of the mouse anti-Mullerian hormone gene suggests a role in both male and female sexual differentiation. — Development (1991)
• Dresser D.W. et al. A GNRP-like gene shares a bidirectional promoter with SAP62 immediately upstream of AMH. (SEP-)
• Johnson J.M. et al. Immunogenicity of anti-Mullerian hormone. (JAN-)
• Dresser D.W. et al. The genes for a spliceosome protein (SAP62) and the anti-Mullerian hormone (AMH) are contiguous. — Hum. Mol. Genet. (1995)
• Church D.M. et al. Lineage-specific biology revealed by a finished genome assembly of the mouse. — PLoS Biol. (2009)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Behringer R.R. et al. Muellerian-inhibiting substance function during mammalian sexual development. — Cell (1994)
• Racine C. et al. Receptors for anti-muellerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation. — Proc. Natl. Acad. Sci. U.S.A. (1998)