Mouse anti-Human/Mouse/Rat sapiens (Human) ANXA11 Monoclonal Antibody
Mouse anti-Human/Mouse/Rat sapiens (Human) ANXA11 Monoclonal Antibody - Image 2
Mouse anti-Human/Mouse/Rat sapiens (Human) ANXA11 Monoclonal Antibody - Image 3

Mouse anti-Human/Mouse/Rat sapiens (Human) ANXA11 Monoclonal Antibody

Mouse anti-Human/Mouse/Rat sapiens (Human) ANXA11 Monoclonal Antibody — Binds specifically to calcyclin in a calcium-dependent manner.

SKU: BCREC-000668MA Category:
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Product Specifications

Uniprot No.P50995
Target NamesANXA11
Species ReactivityMouse
ImmunogenRecombinant Human ANXA11 protein
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeMouse IgG1
ClonalityMonoclonal
ApplicationsELISA, WB, FC, ICC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis.

Biological Context

Subcellular Location: Cytoplasm; Melanosome; Nucleus envelope; Nucleus, nucleoplasm; Cytoplasm, cytoskeleton, spindle
Disease Association: Amyotrophic lateral sclerosis 23 (ALS23) : A form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. ALS23 is an autosomal dominant form with incomplete penetrance. [The disease is caused by variants affecting the gene represented in this entry] | Inclusion body myopathy and brain white matter abnormalities (IBMWMA) : An autosomal dominant, adult-onset disorder characterized predominantly by proximal limb girdle muscle weakness affecting the lower and upper limbs and resulting in gait difficulties and scapular winging. Additional features may include dysarthria, dysphagia, low back pain, and hyporeflexia. Muscle biopsy shows fiber type variation, internal nuclei, rimmed vacuoles, and cytoplasmic protein aggregates or inclusions. Cognitive impairment or frontotemporal dementia occurs in some patients. [The gene represented in this entry is involved in disease pathogenesis]

Product Specifications

Mouse anti-Human/Mouse/Rat sapiens (Human) ANXA11 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis

Subcellular Location

Cytoplasm; Melanosome; Nucleus envelope; Nucleus, nucleoplasm; Cytoplasm, cytoskeleton, spindle

Disease Association

Amyotrophic lateral sclerosis 23 (ALS23) : A form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. ALS23 is an autosomal dominant form with incomplete penetrance. [The disease is caused by variants affecting the gene represented in this entry] | Inclusion body myopathy and brain white matter abnormalities (IBMWMA) : An autosomal dominant, adult-onset disorder characterized predominantly by proximal limb girdle muscle weakness affecting the lower and upper limbs and resulting in gait difficulties and scapular winging. Additional features may include dysarthria, dysphagia, low back pain, and hyporeflexia. Muscle biopsy shows fiber type variation, internal nuclei, rimmed vacuoles, and cytoplasmic protein aggregates or inclusions. Cognitive impairment or frontotemporal dementia occurs in some patients. [The gene represented in this entry is involved in disease pathogenesis]

Subunit

Interacts with S100A6 (PubMed:28469040). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis

Gene: ANXA11  |  Organism: Homo sapiens  |  Synonyms: 56 kDa autoantigen; Annexin XI; Annexin-11; Calcyclin-associated annexin 50
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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