Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody
Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody - Image 2
Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody - Image 3

Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody

Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody — Plays a role in endocytosis and regulates internalization of plasma membrane proteins.

SKU: BCREC-000425MA Category:
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Product Specifications

Uniprot No.Q9UKS6
Target NamesPACSIN3
Species ReactivityMouse
ImmunogenRecombinant Human PACSIN3 protein
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeMouse IgG1
ClonalityMonoclonal
ApplicationsELISA, WB, FC, ICC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.

Biological Context

Subcellular Location: Cytoplasm; Cell membrane (Peripheral membrane protein)
Tissue Specificity: Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney
Disease Association: Congenital myopathy 27 (CMYO27) : A form of congenital myopathy, a clinically and genetically heterogeneous group of muscle disorders characterized by hypotonia and muscle weakness typically noticed at birth or during the neonatal period, and specific pathological features on muscle biopsy. CMYO27 is an autosomal recessive form with mild features beginning in early childhood. Affected children show delayed motor development, exercise intolerance, and easy fatigability. Serum creatine kinase is increased. Fiber size variation and atrophic fibers are seen on muscle biopsy. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity)

Subcellular Location

Cytoplasm; Cell membrane (Peripheral membrane protein)

Disease Association

Congenital myopathy 27 (CMYO27) : A form of congenital myopathy, a clinically and genetically heterogeneous group of muscle disorders characterized by hypotonia and muscle weakness typically noticed at birth or during the neonatal period, and specific pathological features on muscle biopsy. CMYO27 is an autosomal recessive form with mild features beginning in early childhood. Affected children show delayed motor development, exercise intolerance, and easy fatigability. Serum creatine kinase is increased. Fiber size variation and atrophic fibers are seen on muscle biopsy. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney

Subunit

Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYNJ1 and WASL. Interacts with TRPV4 (By similarity)

Gene: PACSIN3  |  Organism: Homo sapiens  |  Synonyms: SH3 domain-containing protein 6511
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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