Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody
Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody - Image 2
Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody - Image 3

Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody

Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody — Plays a role in endocytosis and regulates internalization of plasma membrane proteins.

SKU: BCREC-000425MA Category:
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Product Specifications

Uniprot No.Q9UKS6
Target NamesPACSIN3
Species ReactivityMouse
ImmunogenRecombinant Human PACSIN3 protein
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeMouse IgG1
ClonalityMonoclonal
ApplicationsELISA, WB, FC, ICC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.

Biological Context

Subcellular Location: Cytoplasm; Cell membrane (Peripheral membrane protein)
Tissue Specificity: Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney
Disease Association: Congenital myopathy 27 (CMYO27) : A form of congenital myopathy, a clinically and genetically heterogeneous group of muscle disorders characterized by hypotonia and muscle weakness typically noticed at birth or during the neonatal period, and specific pathological features on muscle biopsy. CMYO27 is an autosomal recessive form with mild features beginning in early childhood. Affected children show delayed motor development, exercise intolerance, and easy fatigability. Serum creatine kinase is increased. Fiber size variation and atrophic fibers are seen on muscle biopsy. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Mouse anti-Human/Mouse/Rat sapiens (Human) PACSIN3 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

Applications: ELISA, WB, FC, ICC

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity)

Subcellular Location

Cytoplasm; Cell membrane (Peripheral membrane protein)

Disease Association

Congenital myopathy 27 (CMYO27) : A form of congenital myopathy, a clinically and genetically heterogeneous group of muscle disorders characterized by hypotonia and muscle weakness typically noticed at birth or during the neonatal period, and specific pathological features on muscle biopsy. CMYO27 is an autosomal recessive form with mild features beginning in early childhood. Affected children show delayed motor development, exercise intolerance, and easy fatigability. Serum creatine kinase is increased. Fiber size variation and atrophic fibers are seen on muscle biopsy. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney

Subunit

Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYNJ1 and WASL. Interacts with TRPV4 (By similarity)

Gene: PACSIN3  |  Organism: Homo sapiens  |  Synonyms: SH3 domain-containing protein 6511
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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