Recombinant Bovine NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR), Bos taurus (Bovine), Yeast, N-terminal 10xHis-tagged, 52.8kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Bovine NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR)

Recombinant Bovine NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) — Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adre… Purity >85%.

SKU: BCRECP-002719 Categories: ,
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Product Specifications

Product SkuBCRECP-002719
Product DescriptionRecombinant Bovine NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) Protein is expressed from Yeast with N-terminal 10xHis-tagged. It contains 33-492aa. [Accession | P08165].
Uniprot No.P08165
Gene NamesFDXR
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region33-492aa
SpeciesBos taurus (Bovine)
Tag InfoN-terminal 10xHis-tagged
Molecular weight52.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Also acts as a ferredoxin–NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6.

Biological Context

Subcellular Location: Mitochondrion inner membrane (Peripheral membrane protein)
Tissue Specificity: Detected in adrenal cortex and corpus luteum (at protein level)
Pathway: Steroid metabolism; cholesterol metabolism

Product Specifications

Recombinant Bovine NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) is a recombinant protein from Bos taurus (Bovine), expressed in Yeast, covering amino acids 33-492aa, with N-terminal 10xHis-tagged tag, molecular weight 52.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver (PubMed:7811729). Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6 (By similarity)

Subcellular Location

Mitochondrion inner membrane (Peripheral membrane protein)

Tissue Specificity

Detected in adrenal cortex and corpus luteum (at protein level)

Subunit

Monomer. Interacts directly with FDX1

Pathway

Steroid metabolism; cholesterol metabolism

Gene: FDXR  |  Organism: Bos taurus  |  Synonyms: Ferredoxin--NADP(+) reductase
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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