Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT), Homo sapiens (Human), E.coli, N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged, 73.3kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT)

Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT) — Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Purity >90%.

SKU: BCRECP-000002 Categories: ,
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Product Specifications

Product SkuBCRECP-000002
Product DescriptionRecombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT) Protein is expressed from E.coli with N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. It contains 29-500aa. [Accession | P80404].
Uniprot No.P80404
Gene NamesABAT
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region29-500aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Molecular weight73.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.

Biological Context

Subcellular Location: Mitochondrion matrix
Tissue Specificity: Liver > pancreas > brain > kidney > heart > placenta
Disease Association: GABA-transaminase deficiency (GABATD) : An enzymatic deficiency resulting in psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. GABATD inheritance is autosomal recessive. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 29-500aa, with N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged tag, molecular weight 73.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). Can also convert delta-aminovalerate and beta-alanine (By similarity)

Subcellular Location

Mitochondrion matrix

Disease Association

GABA-transaminase deficiency (GABATD) : An enzymatic deficiency resulting in psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. GABATD inheritance is autosomal recessive. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Liver > pancreas > brain > kidney > heart > placenta

Subunit

Homodimer; disulfide-linked

Gene: ABAT  |  Organism: Homo sapiens  |  Synonyms: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; Gamma-amino-N-butyrate transaminase; L-AIBAT
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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