Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT), Homo sapiens (Human), E.coli, N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged, 73.3kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT)

Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT) — Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Purity >90%.

SKU: BCRECP-000002 Categories: ,
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Product Specifications

Product SkuBCRECP-000002
Product DescriptionRecombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT) Protein is expressed from E.coli with N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. It contains 29-500aa. [Accession | P80404].
Uniprot No.P80404
Gene NamesABAT
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region29-500aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
Molecular weight73.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.

Biological Context

Subcellular Location: Mitochondrion matrix
Tissue Specificity: Liver > pancreas > brain > kidney > heart > placenta
Disease Association: GABA-transaminase deficiency (GABATD) : An enzymatic deficiency resulting in psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. GABATD inheritance is autosomal recessive. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 29-500aa, with N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged tag, molecular weight 73.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). Can also convert delta-aminovalerate and beta-alanine (By similarity)

Subcellular Location

Mitochondrion matrix

Disease Association

GABA-transaminase deficiency (GABATD) : An enzymatic deficiency resulting in psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. GABATD inheritance is autosomal recessive. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Liver > pancreas > brain > kidney > heart > placenta

Subunit

Homodimer; disulfide-linked

Gene: ABAT  |  Organism: Homo sapiens  |  Synonyms: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; Gamma-amino-N-butyrate transaminase; L-AIBAT
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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