Recombinant Human Baculoviral IAP repeat-containing protein 5 (BIRC5)

Function

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:20627126, PubMed:21364656, PubMed:25778398, PubMed:28218735, PubMed:9859993). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797)

Subcellular Location

Cytoplasm; Nucleus; Chromosome; Chromosome, centromere; Cytoplasm, cytoskeleton, spindle; Chromosome, centromere, kinetochore; Midbody

Tissue Specificity

Expressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed:16329164). Also expressed in various renal cell carcinoma cell lines (PubMed:10626797). Expressed in cochlea including the organ of Corti, the lateral wall, the interdental cells of the Limbus as well as in Schwann cells and cells of the cochlear nerve and the spiral ganglions (at protein level). Not expressed in cells of the inner and outer sulcus or the Reissner's membrane (at protein level) (PubMed:20627126, PubMed:21364656)

Subunit

(Microbial infection) Interacts with Epstein-Barr virus (EBV) EBNA1; this interaction is probably important for EBV episome maintenance in Burkitt's lymphoma cells

• Ambrosini G. et al. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. — Nat. Med. (1997)
• Mahotka C. et al. Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. — Cancer Res. (1999)
• Uren A.G. et al. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. — Curr. Biol. (2000)
• Badran A. et al. Identification of a novel splice variant of the human anti-apoptosis gene survivin. — Biochem. Biophys. Res. Commun. (2004)
• Zheng W. et al. Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells. — DNA Seq. (2005)
• Kageyama H. et al. An isoform of survivin (survivin-beta) which has 23 amino acids insertion into the BIR domain. (JUN-)
• Caldas H. et al. Survivin 2 alpha: a novel survivin splice variant expressed in human malignancies. (FEB-)
• Vietri M.T. et al. Identification of a novel survivin splicing variant 3alpha in acute myeloid leukemia. (NOV-)