Recombinant Human Biliverdin reductase A (BLVRA), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 60.2kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Biliverdin reductase A (BLVRA)

Recombinant Human Biliverdin reductase A (BLVRA) — Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Purity >90%.

SKU: BCRECP-000162 Categories: ,
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Product Specifications

Product SkuBCRECP-000162
Product DescriptionRecombinant Human Biliverdin reductase A (BLVRA) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-296aa. [Accession | P53004].
Uniprot No.P53004
Gene NamesBLVRA
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-296aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight60.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Does not reduce bilirubin IXbeta. Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7).

Biological Context

Subcellular Location: Cytoplasm, cytosol
Tissue Specificity: Liver
Disease Association: Hyperbiliverdinemia (HBLVD) : A condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis. [The disease is caused by variants affecting the gene represented in this entry]
Pathway: Porphyrin-containing compound metabolism; protoheme degradation

Product Specifications

Recombinant Human Biliverdin reductase A (BLVRA) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-296aa, with N-terminal GST-tagged tag, molecular weight 60.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092)

Subcellular Location

Cytoplasm, cytosol

Disease Association

Hyperbiliverdinemia (HBLVD) : A condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Liver

Subunit

Monomer

Pathway

Porphyrin-containing compound metabolism; protoheme degradation

Gene: BLVRA  |  Organism: Homo sapiens  |  Synonyms: Biliverdin-IX alpha-reductase
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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