Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial, Homo sapiens (Human), Yeast, N-terminal Twin-Strep-tagged, 17.2kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial

Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial — Inhibitory receptor acting as a major negative regulator of T-cell responses. Purity >90%.

SKU: BCRECP-000450 Categories: ,
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Product Specifications

Product SkuBCRECP-000450
Product DescriptionRecombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4) Protein is expressed from Yeast with N-terminal Twin-Strep-tagged. It contains 36-161aa. [Accession | P16410].
Uniprot No.P16410
Gene NamesCTLA4
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region36-161aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal Twin-Strep-tagged
Molecular weight17.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation
Disease Association: Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation (IDAIL) : An autosomal dominant primary immunodeficiency characterized by severe autoimmunity, infiltration of non-lymphoid organs, such as the intestine, lungs and brain, by hyperactive T cells and B cells, autoimmune cytopenias, and hypogammaglobulinemia in early childhood. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 36-161aa, with N-terminal Twin-Strep-tagged tag, molecular weight 17.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Inhibitory receptor acting as a major negative regulator of T-cell responses (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:18641304, PubMed:28484017). Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:28484017)

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Disease Association

Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation (IDAIL) : An autosomal dominant primary immunodeficiency characterized by severe autoimmunity, infiltration of non-lymphoid organs, such as the intestine, lungs and brain, by hyperactive T cells and B cells, autoimmune cytopenias, and hypogammaglobulinemia in early childhood. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation

Subunit

Homodimer; disulfide-linked (PubMed:11279501, PubMed:11279502, PubMed:21156796, PubMed:28484017, Ref.24). Interacts with ICOSLG (PubMed:28484017)

Gene: CTLA4  |  Organism: Homo sapiens  |  Synonyms: Cytotoxic T-lymphocyte-associated antigen 4
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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