Recombinant Human Hemicentin-1 (HMCN1), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 19.2kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Hemicentin-1 (HMCN1), partial

Recombinant Human Hemicentin-1 (HMCN1), partial — Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes. Purity >90%.

SKU: BCRECP-000838 Category:
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Product Specifications

Product SkuBCRECP-000838
Product DescriptionRecombinant Human Hemicentin-1 (HMCN1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 4893-5029aa. [Accession | Q96RW7].
Uniprot No.Q96RW7
Gene NamesHMCN1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region4893-5029aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight19.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes. Plays a role in basement membrane organization. May promote cleavage furrow maturation during cytokinesis in preimplantation embryos.

Biological Context

Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane; Cytoplasm; Cell junction; Cleavage furrow
Tissue Specificity: Expressed in skin fibroblasts and retinal pigment epithelium (RPE) cells
Disease Association: Macular degeneration, age-related, 1 (ARMD1) : A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Hemicentin-1 (HMCN1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 4893-5029aa, with N-terminal 6xHis-tagged tag, molecular weight 19.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes (PubMed:29488390). Plays a role in basement membrane organization (By similarity). May promote cleavage furrow maturation during cytokinesis in preimplantation embryos (By similarity). May play a role in the architecture of adhesive and flexible epithelial cell junctions (By similarity). May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration (By similarity)

Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane; Cytoplasm; Cell junction; Cleavage furrow

Disease Association

Macular degeneration, age-related, 1 (ARMD1) : A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in skin fibroblasts and retinal pigment epithelium (RPE) cells

Gene: HMCN1  |  Organism: Homo sapiens  |  Synonyms: Fibulin-6
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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