Recombinant Human Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1), partial, Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 51.0kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1), partial

Recombinant Human Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1), partial — 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Purity >85%.

SKU: BCRECP-000858 Categories: ,
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Product Specifications

Product SkuBCRECP-000858
Product DescriptionRecombinant Human Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 38-411aa. [Accession | O60243].
Uniprot No.O60243
Gene NamesHS6ST1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region38-411aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight51.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development.

Biological Context

Subcellular Location: Membrane (Single-pass type II membrane protein)
Tissue Specificity: Expressed in fetal brain
Disease Association: Hypogonadotropic hypogonadism 15 with or without anosmia (HH15) : A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). [The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry]

Product Specifications

Recombinant Human Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 38-411aa, with C-terminal 6xHis-tagged tag, molecular weight 51.0kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid

Subcellular Location

Membrane (Single-pass type II membrane protein)

Disease Association

Hypogonadotropic hypogonadism 15 with or without anosmia (HH15) : A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). [The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry]

Tissue Specificity

Expressed in fetal brain

Gene: HS6ST1  |  Organism: Homo sapiens
Key Publications

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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