Recombinant Human Hypoxia up-regulated protein 1 (HYOU1), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 37.8kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Hypoxia up-regulated protein 1 (HYOU1), partial

Recombinant Human Hypoxia up-regulated protein 1 (HYOU1), partial — Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Purity >90%.

SKU: BCRECP-000875 Category:
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Product Specifications

Product SkuBCRECP-000875
Product DescriptionRecombinant Human Hypoxia up-regulated protein 1 (HYOU1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 695-994aa. [Accession | Q9Y4L1].
Uniprot No.Q9Y4L1
Gene NamesHYOU1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region695-994aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight37.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress. May play a role as a molecular chaperone and participate in protein folding.

Biological Context

Subcellular Location: Endoplasmic reticulum lumen
Tissue Specificity: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers
Disease Association: Immunodeficiency 59 and hypoglycemia (IMD59) : An autosomal recessive primary immunologic disorder characterized by combined immunodeficiency, granulocytopenia, B-cell and dendritic cell deficiency, recurrent septic infections of the respiratory tract, skin and mucous membranes, and disturbed glucose metabolism. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Hypoxia up-regulated protein 1 (HYOU1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 695-994aa, with N-terminal 6xHis-tagged tag, molecular weight 37.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding

Subcellular Location

Endoplasmic reticulum lumen

Disease Association

Immunodeficiency 59 and hypoglycemia (IMD59) : An autosomal recessive primary immunologic disorder characterized by combined immunodeficiency, granulocytopenia, B-cell and dendritic cell deficiency, recurrent septic infections of the respiratory tract, skin and mucous membranes, and disturbed glucose metabolism. [The disease may be caused by variants affecting the gene represented in this entry]

Tissue Specificity

Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers

Subunit

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX

Gene: HYOU1  |  Organism: Homo sapiens  |  Synonyms: 150 kDa oxygen-regulated protein; 170 kDa glucose-regulated protein; Heat shock protein family H member 4
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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