Recombinant Human Hypoxia up-regulated protein 1 (HYOU1), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 37.8kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Hypoxia up-regulated protein 1 (HYOU1), partial

Recombinant Human Hypoxia up-regulated protein 1 (HYOU1), partial — Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Purity >90%.

SKU: BCRECP-000875 Category:
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Product Specifications

Product SkuBCRECP-000875
Product DescriptionRecombinant Human Hypoxia up-regulated protein 1 (HYOU1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 695-994aa. [Accession | Q9Y4L1].
Uniprot No.Q9Y4L1
Gene NamesHYOU1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region695-994aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight37.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress. May play a role as a molecular chaperone and participate in protein folding.

Biological Context

Subcellular Location: Endoplasmic reticulum lumen
Tissue Specificity: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers
Disease Association: Immunodeficiency 59 and hypoglycemia (IMD59) : An autosomal recessive primary immunologic disorder characterized by combined immunodeficiency, granulocytopenia, B-cell and dendritic cell deficiency, recurrent septic infections of the respiratory tract, skin and mucous membranes, and disturbed glucose metabolism. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Hypoxia up-regulated protein 1 (HYOU1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 695-994aa, with N-terminal 6xHis-tagged tag, molecular weight 37.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding

Subcellular Location

Endoplasmic reticulum lumen

Disease Association

Immunodeficiency 59 and hypoglycemia (IMD59) : An autosomal recessive primary immunologic disorder characterized by combined immunodeficiency, granulocytopenia, B-cell and dendritic cell deficiency, recurrent septic infections of the respiratory tract, skin and mucous membranes, and disturbed glucose metabolism. [The disease may be caused by variants affecting the gene represented in this entry]

Tissue Specificity

Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers

Subunit

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX

Gene: HYOU1  |  Organism: Homo sapiens  |  Synonyms: 150 kDa oxygen-regulated protein; 170 kDa glucose-regulated protein; Heat shock protein family H member 4
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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