Recombinant Human Neuroserpin protein (SERPINI1), Homo sapiens (Human), E.Coli, Tag-Free, 44.7 kDa, purity >>95% as determined by SDS-PAGE.

Recombinant Human Neuroserpin protein (SERPINI1)

Recombinant Human Neuroserpin protein (SERPINI1) — Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. Purity >95%.

SKU: BCACP-000852 Category:
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Product SKUBCACP-000852
Product DescriptionRecombinant Human Neuroserpin protein (SERPINI1) protein is expressed from E.Coli with Tag-Free. It contains 17-410aa. [Accession | Q99574].
Uniprot No.Q99574
Gene NamesSERPINI1
Purity>95% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region17-410aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight44.7 kDa
ActivityFully biologically active when compared to standard. The specific activity determined by fibrining lysis in agarose plate is 8.0x104 IU/mg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesDKFZp781N13156; Neuroserpin; NEUS_HUMAN; Peptidase inhibitor 12; PI-12; PI12; Protease inhibitor 12 ; Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1; Serine or cysteine proteinase inhibitor clade I member 1; Serpin I1; Serpin peptidase inhibitor clade I (neuroserpin) member 1; SERPINI1

Function

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).

Biological Context

Subcellular Location: Secreted; Cytoplasmic vesicle, secretory vesicle lumen; Perikaryon
Tissue Specificity: Detected in brain cortex and hippocampus pyramidal neurons (at protein level). Detected in cerebrospinal fluid (at protein level). Predominantly expressed in the brain
Disease Association: Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB) : A neurodegenerative disease clinically characterized by dementia. Additional features include intellectual decline, psychic seizures, progressive myoclonic epilepsy, and cerebral atrophy. Histologically, it is characterized by the presence of eosinophilic inclusion bodies (called Collins bodies) throughout the deeper layers of the cerebral cortex, leading to neuronal death. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Neuroserpin protein (SERPINI1) is a recombinant protein from Homo sapiens (Human), expressed in E.Coli, covering amino acids 17-410aa, with Tag-Free tag, molecular weight 44.7 kDa, purity >95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:11880376, PubMed:19265707, PubMed:19285087, PubMed:26329378, PubMed:9442076). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable)

Subcellular Location

Secreted; Cytoplasmic vesicle, secretory vesicle lumen; Perikaryon

Disease Association

Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB) : A neurodegenerative disease clinically characterized by dementia. Additional features include intellectual decline, psychic seizures, progressive myoclonic epilepsy, and cerebral atrophy. Histologically, it is characterized by the presence of eosinophilic inclusion bodies (called Collins bodies) throughout the deeper layers of the cerebral cortex, leading to neuronal death. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Detected in brain cortex and hippocampus pyramidal neurons (at protein level) (PubMed:17040209). Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Predominantly expressed in the brain (PubMed:9070919)

Subunit

Monomer. Has a tendency to form large polymers already at 41 and 45 degrees Celsius (in vitro)

Gene: SERPINI1  |  Organism: Homo sapiens  |  Synonyms: Peptidase inhibitor 12; Serpin I1
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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