Recombinant Human Notch homolog 2 N-terminal-like protein B (NOTCH2NLB), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 34.9kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Notch homolog 2 N-terminal-like protein B (NOTCH2NLB)

Recombinant Human Notch homolog 2 N-terminal-like protein B (NOTCH2NLB) — Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Purity >85%.

SKU: BCRECP-001249 Category:
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Product Specifications

Product SkuBCRECP-001249
Product DescriptionRecombinant Human Notch homolog 2 N-terminal-like protein B (NOTCH2NLB) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 26-275aa. [Accession | P0DPK3].
Uniprot No.P0DPK3
Gene NamesNOTCH2NLB
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region26-275aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight34.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research Areasothers

Function

Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed in radial glia neural stem cells during cortical development
Disease Association: [Defects in NOTCH2NLB may be a cause of chromosome 1q21.1 deletion/duplication syndrome. Deletions of NOTCH2NL (NOTCH2NLA, NOTCH2NLB and/or NOTCH2NLC) are present in patients affected by microcephaly, whereas macrocephaly is observed in patients with NOTCH2NL duplications ]

Product Specifications

Recombinant Human Notch homolog 2 N-terminal-like protein B (NOTCH2NLB) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 26-275aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 34.9kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29561261, PubMed:29856954, PubMed:29856955). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955)

Subcellular Location

Secreted

Disease Association

[Defects in NOTCH2NLB may be a cause of chromosome 1q21.1 deletion/duplication syndrome (PubMed:29856954). Deletions of NOTCH2NL (NOTCH2NLA, NOTCH2NLB and/or NOTCH2NLC) are present in patients affected by microcephaly, whereas macrocephaly is observed in patients with NOTCH2NL duplications (PubMed:29856954)]

Tissue Specificity

Expressed in radial glia neural stem cells during cortical development

Subunit

Interacts with NOTCH2 (PubMed:29856954). Interacts with DLL1; the interaction is direct (PubMed:29856955)

Gene: NOTCH2NLB  |  Organism: Homo sapiens

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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