Recombinant Human Profilin-1 (PFN1), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 41.9kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Profilin-1 (PFN1)

Recombinant Human Profilin-1 (PFN1) — Binds to actin and affects the structure of the cytoskeleton. Purity >90%.

SKU: BCRECP-001369 Category:
Online Inquiry →

Product Specifications

Product SkuBCRECP-001369
Product DescriptionRecombinant Human Profilin-1 (PFN1) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 2-140aa. [Accession | P07737].
Uniprot No.P07737
Gene NamesPFN1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-140aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight41.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Biological Context

Subcellular Location: Cytoplasm, cytoskeleton
Tissue Specificity: Expressed in epididymis (at protein level)
Disease Association: Amyotrophic lateral sclerosis 18 (ALS18) : A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Profilin-1 (PFN1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-140aa, with N-terminal GST-tagged tag, molecular weight 41.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR

Subcellular Location

Cytoplasm, cytoskeleton

Disease Association

Amyotrophic lateral sclerosis 18 (ALS18) : A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in epididymis (at protein level)

Subunit

Found in a complex with XPO6, Ran, ACTB and PFN1 (PubMed:14592989). Interacts with ACTB (PubMed:10411937). Interacts with VASP (PubMed:17914456, PubMed:18689676). Interacts with HTT (PubMed:18573880). Interacts with SH3BGRL (PubMed:34331014). Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio (PubMed:17914456, PubMed:18689676). Interacts with ACTMAP (PubMed:36173861)

Gene: PFN1  |  Organism: Homo sapiens  |  Synonyms: Epididymis tissue protein Li 184a; Profilin I
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

Shopping Cart
Scroll to Top