Recombinant Human Protein-glutamine gamma-glutamyltransferase 2 (TGM2), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 76.9kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Protein-glutamine gamma-glutamyltransferase 2 (TGM2), partial

Recombinant Human Protein-glutamine gamma-glutamyltransferase 2 (TGM2), partial — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-001769 Categories: ,
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Product Specifications

Product SkuBCRECP-001769
Product DescriptionRecombinant Human Protein-glutamine gamma-glutamyltransferase 2 (TGM2) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 4-544aa. [Accession | P21980].
Uniprot No.P21980
Gene NamesTGM2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region4-544aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight76.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity.

Biological Context

Subcellular Location: Cytoplasm, perinuclear region
Disease Association: [TGM2 constitutes the major autoantigen in celiac disease, a multifactorial chronic disorder of the small intestine caused by intolerance to gluten. Celiac disease is characterized by immune-mediated enteropathy associated with failed intestinal absorption and malnutrition: intestinal inflammation is precipitated by ingestion of the protein gliadin, a component of wheat gluten in the diet. TGM2 is the main target for celiac disease-associated anti-endomysium autoantibodies. It mediates its effect by catalyzing specific deamidation of gliadin; this deamidation creates an epitope that binds efficiently to HLA-DQ2 and is recognized by gut-derived T-cells ]

Product Specifications

Recombinant Human Protein-glutamine gamma-glutamyltransferase 2 (TGM2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 4-544aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 76.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity

Subcellular Location

Cytoplasm, perinuclear region

Disease Association

[TGM2 constitutes the major autoantigen in celiac disease, a multifactorial chronic disorder of the small intestine caused by intolerance to gluten (PubMed:9212111, PubMed:9623982). Celiac disease is characterized by immune-mediated enteropathy associated with failed intestinal absorption and malnutrition: intestinal inflammation is precipitated by ingestion of the protein gliadin, a component of wheat gluten in the diet (PubMed:9212111, PubMed:9623982). TGM2 is the main target for celiac disease-associated anti-endomysium autoantibodies (PubMed:9212111). It mediates its effect by catalyzing specific deamidation of gliadin; this deamidation creates an epitope that binds efficiently to HLA-DQ2 and is recognized by gut-derived T-cells (PubMed:9623982)]

Subunit

Homooligomer

Gene: TGM2  |  Organism: Homo sapiens  |  Synonyms: Erythrocyte transglutaminase; Heart G alpha(h); Isopeptidase TGM2; Protein G alpha(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; Tissue transglutaminase; Transglutaminase C; Transglutaminase H; Transglutaminase II; Transglutaminase-2
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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