Function
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).
Biological Context
Subcellular Location: Nucleus; Cytoplasm; Cell projection, microvillus membrane
Tissue Specificity: Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias
Product Specifications
Recombinant Human Protein S100-P (S100P) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-95aa, with C-terminal 6xHis-tagged tag, molecular weight 17.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
