Function
Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
Biological Context
Subcellular Location: Cytoplasm; Nucleus
Tissue Specificity: Expressed in testis. Constitutively expressed in acute myeloid leukemia (AML)
Disease Association: Duane-radial ray syndrome (DRRS) : Disorder characterized by the association of forearm malformations with Duane retraction syndrome. [The disease is caused by variants affecting the gene represented in this entry] | IVIC syndrome (IVIC) : An autosomal dominant condition characterized by upper limbs anomalies (radial ray defects, carpal bones fusion), extraocular motor disturbances, congenital bilateral non-progressive mixed hearing loss. Other less consistent malformations include heart involvement, mild thrombocytopenia and leukocytosis (before age 50), shoulder girdle hypoplasia, imperforate anus, kidney malrotation or rectovaginal fistula. The IVIC syndrome is an allelic disorder of Duane-radial ray syndrome with a similar phenotype. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Sal-like protein 4 (SALL4), partial is a recombinant protein from Homo sapiens (Human), expressed in Baculovirus, covering amino acids 954-1053aa+11R, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 16kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
