Recombinant Human Transcriptional enhancer factor TEF-1 (TEAD1), partial, Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 26.6kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Transcriptional enhancer factor TEF-1 (TEAD1), partial

Recombinant Human Transcriptional enhancer factor TEF-1 (TEAD1), partial — Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Purity >95%.

SKU: BCRECP-001749 Category:
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Product Specifications

Product SkuBCRECP-001749
Product DescriptionRecombinant Human Transcriptional enhancer factor TEF-1 (TEAD1) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 210-426aa. [Accession | P28347].
Uniprot No.P28347
Gene NamesTEAD1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region210-426aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight26.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction.

Biological Context

Subcellular Location: Nucleus
Tissue Specificity: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart
Disease Association: Sveinsson chorioretinal atrophy (SCRA) : Characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Transcriptional enhancer factor TEF-1 (TEAD1), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 210-426aa, with N-terminal 6xHis-tagged tag, molecular weight 26.6kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif

Subcellular Location

Nucleus

Disease Association

Sveinsson chorioretinal atrophy (SCRA) : Characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart

Subunit

Interacts with YAP1 and WWTR1/TAZ

Gene: TEAD1  |  Organism: Homo sapiens  |  Synonyms: NTEF-1; Protein GT-IIC; TEA domain family member 1; Transcription factor 13
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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