Recombinant Rabbit T cell immunoreceptor with Ig and ITIM domains (TIGIT), partial, Oryctolagus cuniculus (Rabbit), Mammalian cell, C-terminal hFc1-tagged, 42.7kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Rabbit T cell immunoreceptor with Ig and ITIM domains (TIGIT), partial

Recombinant Rabbit T cell immunoreceptor with Ig and ITIM domains (TIGIT), partial — Inhibitory receptor that plays a role in the modulation of immune responses. Purity >90%.

SKU: BCRECP-004569 Categories: ,
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Product Specifications

Product SkuBCRECP-004569
Product DescriptionRecombinant Rabbit T cell immunoreceptor with Ig and ITIM domains (TIGIT) Protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 16-142aa. [Accession | G1SLC1].
Uniprot No.G1SLC1
Gene NamesTIGIT
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region16-142aa
SpeciesOryctolagus cuniculus (Rabbit)
Tag InfoC-terminal hFc1-tagged
Molecular weight42.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)

Product Specifications

Recombinant Rabbit T cell immunoreceptor with Ig and ITIM domains (TIGIT), partial is a recombinant protein from Oryctolagus cuniculus (Rabbit), expressed in Mammalian cell, covering amino acids 16-142aa, with C-terminal hFc1-tagged tag, molecular weight 42.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway. Also acts as a receptor for NECTIN4 to inhibit NK cell cytotoxicity

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Subunit

Homodimer in cis; binds with high affinity to PVR, forming a heterotetrameric assembly of two TIGIT and two PVR molecules. Binds with lower affinity to NECTIN2 and NECTIN3. Interacts with GRB2. Interacts with NECTIN4

Gene: TIGIT  |  Organism: Oryctolagus cuniculus  |  Synonyms: V-set and transmembrane domain-containing protein 3

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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