Recombinant Rabbit T cell immunoreceptor with Ig and ITIM domains (TIGIT), partial, Oryctolagus cuniculus (Rabbit), Mammalian cell, C-terminal hFc1-tagged, 42.7kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Rabbit T cell immunoreceptor with Ig and ITIM domains (TIGIT), partial

Recombinant Rabbit T cell immunoreceptor with Ig and ITIM domains (TIGIT), partial — Inhibitory receptor that plays a role in the modulation of immune responses. Purity >90%.

SKU: BCRECP-004569 Categories: ,
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Product Specifications

Product SkuBCRECP-004569
Product DescriptionRecombinant Rabbit T cell immunoreceptor with Ig and ITIM domains (TIGIT) Protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 16-142aa. [Accession | G1SLC1].
Uniprot No.G1SLC1
Gene NamesTIGIT
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region16-142aa
SpeciesOryctolagus cuniculus (Rabbit)
Tag InfoC-terminal hFc1-tagged
Molecular weight42.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)

Product Specifications

Recombinant Rabbit T cell immunoreceptor with Ig and ITIM domains (TIGIT), partial is a recombinant protein from Oryctolagus cuniculus (Rabbit), expressed in Mammalian cell, covering amino acids 16-142aa, with C-terminal hFc1-tagged tag, molecular weight 42.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway. Also acts as a receptor for NECTIN4 to inhibit NK cell cytotoxicity

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Subunit

Homodimer in cis; binds with high affinity to PVR, forming a heterotetrameric assembly of two TIGIT and two PVR molecules. Binds with lower affinity to NECTIN2 and NECTIN3. Interacts with GRB2. Interacts with NECTIN4

Gene: TIGIT  |  Organism: Oryctolagus cuniculus  |  Synonyms: V-set and transmembrane domain-containing protein 3

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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