Recombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 (Gp2), Mus musculus (Mouse), Yeast, N-terminal 6xHis-tagged, 59.0kDa, purity >85% as determined by SDS-PAGE.

Recombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 (Gp2)

Recombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 (Gp2) — Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. Purity >85%.

SKU: BCRECP-002891 Category:
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Product Specifications

Product SkuBCRECP-002891
Product DescriptionRecombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 (Gp2) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 22-531aa. [Accession | Q9D733].
Uniprot No.Q9D733
Gene NamesGp2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region22-531aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight59.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.

Biological Context

Subcellular Location: Zymogen granule membrane (Lipid-anchor, GPI-anchor); Secreted; Cell membrane (Lipid-anchor, GPI-anchor); Apical cell membrane (Lipid-anchor, GPI-anchor); Membrane raft (Lipid-anchor, GPI-anchor); Endosome
Tissue Specificity: Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine

Product Specifications

Recombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 (Gp2) is a recombinant protein from Mus musculus (Mouse), expressed in Yeast, covering amino acids 22-531aa, with N-terminal 6xHis-tagged tag, molecular weight 59.0kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response

Subcellular Location

Zymogen granule membrane (Lipid-anchor, GPI-anchor); Secreted; Cell membrane (Lipid-anchor, GPI-anchor); Apical cell membrane (Lipid-anchor, GPI-anchor); Membrane raft (Lipid-anchor, GPI-anchor); Endosome

Tissue Specificity

Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine

Subunit

Interacts with SYCN. Interacts with bacterial adhesin fimH

Gene: Gp2  |  Organism: Mus musculus  |  Synonyms: Pancreatic zymogen granule membrane protein GP-2

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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