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Recombinant Human BDNF/NT-3 growth factors receptor Protein

Recombinant Human BDNF/NT-3 growth factors receptor Protein — Important signaling molecule that activates signaling cascades downstream of NTRK2. Purity >85%.

SKU: BCRETP-000024 Categories: ,

Product Specifications

Product SkuBCRETP-000024
Product DescriptionRecombinant Human BDNF/NT-3 growth factors receptor Protein is expressed from Insect Cells with His tag at the N-Terminus. It contains 32-430aa. [Accession | P23560].
Uniprot No.P23560
SynonymsGP145-TrkB, trk-B, TRKB, NTRK2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemInsect cell
Expression Region32-430aa
Tag InfoN-6His
Molecular weight45.2kDa (407aa), 57-70kDa (SDS-PAGE under reducing conditions)
EndotoxinLess than 1.0 EU/μg as determined by LAL method.

Function

Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD).

Product Specifications

Recombinant Human BDNF/NT-3 growth factors receptor Protein is a recombinant protein, expressed in Insect cell, covering amino acids 32-430aa, with N-6His tag, molecular weight 45.2kDa (407aa), 57-70kDa (SDS-PAGE under reducing conditions), purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Protein Biology

Function

Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity)

Gene: BDNF  |  Organism: Homo sapiens

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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