Recombinant Macaca mulatta (Rhesus macaque) Interleukin-1 alpha (IL1A), Macaca mulatta (Rhesus macaque), E.coli, N-terminal 6xHis-SUMO-tagged, 34.1kDa, purity >90% as determined by SDS-PAGE.
,

Recombinant Macaca mulatta (Rhesus macaque) Interleukin-1 alpha (IL1A)

Recombinant Macaca mulatta (Rhesus macaque) Interleukin-1 alpha (IL1A) — Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. Purity >90%.

SKU: BCRECP-003127 Categories: ,
Online Inquiry →

Product Specifications

Product SkuBCRECP-003127
Product DescriptionRecombinant Macaca mulatta (Rhesus macaque) Interleukin-1 alpha (IL1A) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 113-271aa. [Accession | P48089].
Uniprot No.P48089
Gene NamesIL1A
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region113-271aa
SpeciesMacaca mulatta (Rhesus macaque)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight34.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.

Biological Context

Subcellular Location: Nucleus; Cytoplasm; Secreted

Product Specifications

Recombinant Macaca mulatta (Rhesus macaque) Interleukin-1 alpha (IL1A) is a recombinant protein from Macaca mulatta (Rhesus macaque), expressed in E.coli, covering amino acids 113-271aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 34.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity

Subcellular Location

Nucleus; Cytoplasm; Secreted

Subunit

Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane

Gene: IL1A  |  Organism: Macaca mulatta  |  Synonyms: Hematopoietin-1

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

Shopping Cart
Scroll to Top