Recombinant Mouse Lymphocyte activation gene 3 protein (Lag3), partial, Mus musculus (Mouse), Mammalian cell, C-terminal 10xHis-tagged, 46.6kDa, purity >95% as determined by SDS-PAGE.

Recombinant Mouse Lymphocyte activation gene 3 protein (Lag3), partial

Recombinant Mouse Lymphocyte activation gene 3 protein (Lag3), partial — recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell. Purity >95%.

SKU: BCRECP-003237 Category:
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Product Specifications

Product SkuBCRECP-003237
Product DescriptionRecombinant Mouse Lymphocyte activation gene 3 protein (Lag3) Protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 24-442aa. [Accession | Q61790].
Uniprot No.Q61790
Gene NamesLag3
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region24-442aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 10xHis-tagged
Molecular weight46.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Primarily expressed in activated CD4(+) and CD8(+) T-cells. Also expressed in a subset of regulatory T-cells (Tregs), such as natural CD4(+)CD25(+) Tregs. Also expressed on plasmacytoid dendritic cells (pDCs)

Product Specifications

Recombinant Mouse Lymphocyte activation gene 3 protein (Lag3), partial is a recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell, covering amino acids 24-442aa, with C-terminal 10xHis-tagged tag, molecular weight 46.6kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response

Subcellular Location

Secreted

Tissue Specificity

Primarily expressed in activated CD4(+) and CD8(+) T-cells (PubMed:12209638). Also expressed in a subset of regulatory T-cells (Tregs), such as natural CD4(+)CD25(+) Tregs (PubMed:15485628). Also expressed on plasmacytoid dendritic cells (pDCs) (PubMed:19201841)

Subunit

Homodimer (PubMed:35761082, PubMed:38483996, PubMed:39209860). Interacts with CD3E; disrupting the association between CD3E and LCK, thereby preventing TCR activation (PubMed:40592325)

Gene: Lag3  |  Organism: Mus musculus  |  Synonyms: Activation-induced cytidine deaminase-linked autoimmunity protein
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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