Mouse anti-Human sapiens (Human) TRIM34 Monoclonal Antibody
Mouse anti-Human sapiens (Human) TRIM34 Monoclonal Antibody - Image 2
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Mouse anti-Human sapiens (Human) TRIM34 Monoclonal Antibody

Mouse anti-Human sapiens (Human) TRIM34 Monoclonal Antibody — Functions as antiviral protein and contributes to the defense against retroviral infections.

SKU: BCREC-000461MA Category:
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Product Specifications

Uniprot No.Q9BYJ4
Target NamesTRIM34
Species ReactivityMouse
ImmunogenRecombinant Human TRIM34 protein
Immunogen SpeciesHomo sapiens (Human)
ConjugateNon-conjugated
IsotypeMouse IgG2a
ClonalityMonoclonal
ApplicationsELISA, WB, FC
BufferPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Function

Functions as antiviral protein and contributes to the defense against retroviral infections. Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination.

Biological Context

Subcellular Location: Cytoplasm; Mitochondrion
Tissue Specificity: Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes
Pathway: Protein modification; protein ubiquitination

Product Specifications

Mouse anti-Human sapiens (Human) TRIM34 Monoclonal Antibody is a recombinant protein. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses (PubMed:32282853). During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination (PubMed:35065966). In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (PubMed:35065966). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis (PubMed:31956709). Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (PubMed:31487507)

Subcellular Location

Cytoplasm; Mitochondrion

Tissue Specificity

Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes

Subunit

(Microbial infection) Interacts (via the B30.2/SPRY domain) with HIV-1 capsid complexes (PubMed:17156811)

Pathway

Protein modification; protein ubiquitination

Gene: TRIM34  |  Organism: Homo sapiens  |  Synonyms: Interferon-responsive finger protein 1; RING finger protein 21
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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