Recombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1), partial (Active), Homo sapiens (Human), Baculovirus, C-terminal 6xHis-tagged, 11.5KDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1), partial (Active)

Recombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1), partial (Active) — Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. Purity >95%.

SKU: BCACP-000250 Categories: , ,
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Product SKUBCACP-000250
Product DescriptionRecombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1) protein is expressed from Baculovirus with C-terminal 6xHis-tagged. It contains 22-118aa. [Accession | P37023].
Uniprot No.P37023
Gene NamesACVRL1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemBaculovirus
Expression Region22-118aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight11.5KDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human CCR9 at 10 μg/mL can bind Anti-CCR9 recombinant antibody . The EC50 is 31.67-36.83 ng/mL.The VLPs is negative control.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesACVRLK1;ALK1;

Function

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Disease Association: Telangiectasia, hereditary hemorrhagic, 2 (HHT2) : A multisystemic vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera. The disease is characterized by recurrent epistaxis and gastro-intestinal hemorrhage. Visceral involvement includes arteriovenous malformations of the lung, liver, and brain. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Baculovirus, covering amino acids 22-118aa, with C-terminal 6xHis-tagged tag, molecular weight 11.5KDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Catalog number: BCACP-000250.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Disease Association

Telangiectasia, hereditary hemorrhagic, 2 (HHT2) : A multisystemic vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera. The disease is characterized by recurrent epistaxis and gastro-intestinal hemorrhage. Visceral involvement includes arteriovenous malformations of the lung, liver, and brain. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Interacts with TSC22D1/TSC-22

Gene: ACVRL1  |  Organism: Homo sapiens  |  Synonyms: Activin receptor-like kinase 1; Serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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