Function
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation.
Biological Context
Subcellular Location: Cytoplasm, cytoskeleton; Cytoplasm, cell cortex
Tissue Specificity: Smooth muscle tissues and in some, but not all, nonmuscle cells
Disease Association: Megacystis-microcolon-intestinal hypoperistalsis syndrome 4 (MMIHS4) : A form of megacystis-microcolon-intestinal hypoperistalsis syndrome, a congenital visceral myopathy primarily affecting females, and characterized by loss of smooth muscle contraction in the bladder and intestine. Affected individuals present at birth with functional obstruction of intestine, microcolon, dilation of bladder, and secondary hydronephrosis. The majority of cases have a fatal outcome due to malnutrition and sepsis, followed by multiorgan failure. MMIHS4 inheritance is autosomal recessive. [The disease may be caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Myosin regulatory light polypeptide 9 (MYL9) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 2-172aa, with C-terminal 10xHis-tagged tag, molecular weight 21.7kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
