Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 34.3 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) (Active)

Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) (Active) — Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Purity >95%.

SKU: BCACP-000261 Category:
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Product SKUBCACP-000261
Product DescriptionRecombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 35-320aa. [Accession | P31997].
Uniprot No.P31997
Gene NamesCEACAM8
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region35-320aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight34.3 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human BTLA at 2 μg/mL can bind Anti-BTLA recombinant antibody. The EC50 is 11.56-13.00 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCGM6

Function

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.

Biological Context

Subcellular Location: Cell membrane (Lipid-anchor, GPI-anchor); Cell surface
Tissue Specificity: Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow

Product Specifications

Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 8(CEACAM8) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 35-320aa, with C-terminal 10xHis-tagged tag, molecular weight 34.3 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:11590190, PubMed:2022629, PubMed:8776764). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:11590190, PubMed:2022629, PubMed:8776764). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764)

Subcellular Location

Cell membrane (Lipid-anchor, GPI-anchor); Cell surface

Tissue Specificity

Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow

Subunit

Monomer. Heterodimer with CEACAM6; heterodimerizes via its Ig-like V-type domain

Gene: CEACAM8  |  Organism: Homo sapiens  |  Synonyms: CD67 antigen; Carcinoembryonic antigen CGM6; Carcinoembryonic antigen-related cell adhesion molecule 8; Non-specific cross-reacting antigen NCA-95
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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