Recombinant Human Receptor-type tyrosine-protein phosphatase C (PTPRC), partial (Active)

Function

(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Membrane raft; Synapse

Disease Association

Multiple sclerosis (MS) : A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. [Disease susceptibility may be associated with variants affecting the gene represented in this entry] | Immunodeficiency 105, severe combined (IMD105) : An autosomal recessive disorder characterized by recurrent infections in early infancy, decreased or absent numbers of non-functional T cells, normal or increased levels of B cells, hypogammaglobulinemia, and normal or low NK cells. Clinical manifestations may include pneumonia, dermatitis, and lymphadenopathy. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes

Subunit

(Microbial infection) Interacts with human cytomegalovirus protein UL11; the interaction is required for binding of UL11 to T-cells

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• Tsai A.Y.M. et al. Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA. — Mol. Cell. Biol. (1989)
• Hall L.R. et al. Complete exon-intron organization of the human leukocyte common antigen (CD45) gene. — J. Immunol. (1988)
• Charbonneau H. et al. The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase. — Proc. Natl. Acad. Sci. U.S.A. (1988)