Recombinant Human Ubiquitin-associated domain-containing protein 1 (UBAC1) (Active), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 72.3 kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Ubiquitin-associated domain-containing protein 1 (UBAC1) (Active)

Recombinant Human Ubiquitin-associated domain-containing protein 1 (UBAC1) (Active) — Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1. Purity >85%.

SKU: BCACP-000001 Category:
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Product SKUBCACP-000001
Product DescriptionRecombinant Human Ubiquitin-associated domain-containing protein 1 (UBAC1) protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-405aa. [Accession | Q9BSL1].
Uniprot No.Q9BSL1
Gene NamesUBAC1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-405aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight72.3 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized CCL5 at 2 μg/ml can bind human UBAC1, the EC50 of human UBAC1 protein is 86.67-97.25 μg/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesUBAC1; GBDR1; KPC2; UBADC1; Ubiquitin-associated domain-containing protein 1; UBA domain-containing protein 1; E3 ubiquitin-protein ligase subunit KPC2; Glialblastoma cell differentiation-related protein 1; Kip1 ubiquitination-promoting complex protein 2

Function

Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1. The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Ubiquitous
Pathway: Protein modification; protein ubiquitination

Product Specifications

Recombinant Human Ubiquitin-associated domain-containing protein 1 (UBAC1) (Active) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-405aa, with N-terminal GST-tagged tag, molecular weight 72.3 kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized CCL5 at 2 μg/ml can bind human UBAC1, the EC50 of human UBAC1 protein is 86.67-97.25 μg/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1 (PubMed:15531880, PubMed:15746103, PubMed:16227581, PubMed:25860612). The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (PubMed:15531880, PubMed:15746103). The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor (PubMed:25860612). Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome (PubMed:16227581)

Subcellular Location

Cytoplasm

Tissue Specificity

Ubiquitous

Subunit

Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2 (PubMed:15531880, PubMed:15746103, PubMed:16227581). Interacts (via ubiquitin-like domain) with RNF123 (PubMed:15746103, PubMed:16227581). Interacts (via ubiquitin-like and UBA domains) with the proteasome via its N-terminal domain (PubMed:15746103, PubMed:16227581)

Pathway

Protein modification; protein ubiquitination

Gene: UBAC1  |  Organism: Homo sapiens  |  Synonyms: Glialblastoma cell differentiation-related protein 1; Kip1 ubiquitination-promoting complex protein 2
Key Publications

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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