Recombinant Human Mitochondrial thiamine pyrophosphate carrier (SLC25A19) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 37.0kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Mitochondrial thiamine pyrophosphate carrier (SLC25A19) Protein

Recombinant Human Mitochondrial thiamine pyrophosphate carrier (SLC25A19) Protein — Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. Purity >85%.

SKU: BCRECP-00220TM Category:
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Product Specifications

Uniprot No.Q9HC21
Gene NamesSLC25A19
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-320aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight37.0kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.

Biological Context

Subcellular Location: Mitochondrion membrane (Multi-pass membrane protein)
Tissue Specificity: Expressed in all tissues examined except for placenta. Highest levels in colon, kidney, lung, testis, spleen, and brain
Disease Association: Microcephaly, Amish type (MCPHA) : A disorder characterized by severe congenital microcephaly and severe 2-ketoglutaric aciduria leading to death within the first year. [The disease is caused by variants affecting the gene represented in this entry] | Thiamine metabolism dysfunction syndrome 4, bilateral striatal degeneration and progressive polyneuropathy type (THMD4) : A disease characterized by recurrent episodes of flaccid paralysis and encephalopathy associated with bilateral striatal necrosis and chronic progressive polyneuropathy. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Mitochondrial thiamine pyrophosphate carrier (SLC25A19) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-320aa, with N-terminal 10xHis-tagged tag, molecular weight 37.0kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient

Subcellular Location

Mitochondrion membrane (Multi-pass membrane protein)

Disease Association

Microcephaly, Amish type (MCPHA) : A disorder characterized by severe congenital microcephaly and severe 2-ketoglutaric aciduria leading to death within the first year. [The disease is caused by variants affecting the gene represented in this entry] | Thiamine metabolism dysfunction syndrome 4, bilateral striatal degeneration and progressive polyneuropathy type (THMD4) : A disease characterized by recurrent episodes of flaccid paralysis and encephalopathy associated with bilateral striatal necrosis and chronic progressive polyneuropathy. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in all tissues examined except for placenta. Highest levels in colon, kidney, lung, testis, spleen, and brain

Gene: SLC25A19  |  Organism: Homo sapiens  |  Synonyms: Mitochondrial thiamine pyrophosphate transporter; Mitochondrial uncoupling protein 1; Solute carrier family 25 member 19
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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