Recombinant Human CX3C chemokine receptor 1 (CX3CR1)-VLPs Protein, Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 41.8kDa, purity >VLPs
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Recombinant Human CX3C chemokine receptor 1 (CX3CR1)-VLPs Protein

Recombinant Human CX3C chemokine receptor 1 (CX3CR1)-VLPs Protein — (Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein. Purity VLPs.

SKU: BCRECP-00454TM Categories: , ,
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Product Specifications

Uniprot No.P49238
Gene NamesCX3CR1
PurityVLPs
Expression SystemMammalian cell
Expression Region1-355aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight41.8kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

(Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein. May have more potent HIV-1 coreceptor activity than isoform 1.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Expressed in lymphoid and neural tissues. Expressed in lymphocyte subsets, such as natural killer (NK) cells, gamma-delta T-cells and terminally differentiated CD8(+) T-cells. Expressed in smooth muscle cells in atherosclerotic plaques
Disease Association: Macular degeneration, age-related, 12 (ARMD12) : A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. [Disease susceptibility is associated with variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human CX3C chemokine receptor 1 (CX3CR1)-VLPs Protein is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 1-355aa, with C-terminal 10xHis-tagged tag, molecular weight 41.8kDa, purity VLPs. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

(Microbial infection) Acts as a coreceptor with CD4 for HIV-1 virus envelope protein (PubMed:14607932). May have more potent HIV-1 coreceptor activity than isoform 1 (PubMed:14607932)

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Disease Association

Macular degeneration, age-related, 12 (ARMD12) : A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. [Disease susceptibility is associated with variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in lymphoid and neural tissues (PubMed:7590284). Expressed in lymphocyte subsets, such as natural killer (NK) cells, gamma-delta T-cells and terminally differentiated CD8(+) T-cells (PubMed:12055230). Expressed in smooth muscle cells in atherosclerotic plaques (PubMed:14581400)

Subunit

(Microbial infection) Interacts with HIV-1 envelope polyprotein gp160

Gene: CX3CR1  |  Organism: Homo sapiens  |  Synonyms: Beta chemokine receptor-like 1; Fractalkine receptor; G protein-coupled receptor 13; V28
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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