Recombinant Human Protein argonaute-2 (AGO2), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 38.1kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Protein argonaute-2 (AGO2), partial

Recombinant Human Protein argonaute-2 (AGO2), partial — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-000043 Category:
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Product Specifications

Product SkuBCRECP-000043
Product DescriptionRecombinant Human Protein argonaute-2 (AGO2) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 517-818aa. [Accession | Q9UKV8].
Uniprot No.Q9UKV8
Gene NamesAGO2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region517-818aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight38.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

(Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response.

Biological Context

Subcellular Location: Cytoplasm, P-body; Nucleus
Disease Association: Lessel-Kreienkamp syndrome (LESKRES) : An autosomal dominant disorder characterized by global developmental delay, intellectual disability of variable degree, and speech and language delay apparent from infancy or early childhood. Behavioral disorders are observed in most patients. Additional variable features include seizures, hypotonia, gait abnormalities, visual and cardiac defects, and non-specific facial dysmorphism. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Protein argonaute-2 (AGO2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 517-818aa, with N-terminal 6xHis-tagged tag, molecular weight 38.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

(Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response

Subcellular Location

Cytoplasm, P-body; Nucleus

Disease Association

Lessel-Kreienkamp syndrome (LESKRES) : An autosomal dominant disorder characterized by global developmental delay, intellectual disability of variable degree, and speech and language delay apparent from infancy or early childhood. Behavioral disorders are observed in most patients. Additional variable features include seizures, hypotonia, gait abnormalities, visual and cardiac defects, and non-specific facial dysmorphism. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

(Microbial infection) Interacts with human herpesvirus 8 protein MTA/ORF57; this interaction inhibits P-body formation

Gene: AGO2  |  Organism: Homo sapiens  |  Synonyms: Argonaute RISC catalytic component 2; Eukaryotic translation initiation factor 2C 2; PAZ Piwi domain protein; Protein slicer
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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