Recombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 25.9kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L)

Recombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L) — Induces apoptosis. Purity >90%.

SKU: BCRECP-000170 Categories: ,
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Product Specifications

Product SkuBCRECP-000170
Product DescriptionRecombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 1-219aa. [Accession | O60238].
Uniprot No.O60238
Gene NamesBNIP3L
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-219aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight25.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis.

Biological Context

Subcellular Location: Nucleus envelope; Endoplasmic reticulum; Mitochondrion outer membrane; Membrane (Single-pass membrane protein)

Product Specifications

Recombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-219aa, with N-terminal 6xHis-tagged tag, molecular weight 25.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor

Subcellular Location

Nucleus envelope; Endoplasmic reticulum; Mitochondrion outer membrane; Membrane (Single-pass membrane protein)

Subunit

(Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus protein VIRF-1

Gene: BNIP3L  |  Organism: Homo sapiens  |  Synonyms: Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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