Recombinant Human Cold-inducible RNA-binding protein (CIRBP), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 50.2kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Cold-inducible RNA-binding protein (CIRBP)

Recombinant Human Cold-inducible RNA-binding protein (CIRBP) — Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Purity >95%.

SKU: BCRECP-000370 Category:
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Product Specifications

Product SkuBCRECP-000370
Product DescriptionRecombinant Human Cold-inducible RNA-binding protein (CIRBP) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-172aa. [Accession | Q14011].
Uniprot No.Q14011
Gene NamesCIRBP
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-172aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight50.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation.

Biological Context

Subcellular Location: Nucleus, nucleoplasm; Cytoplasm
Tissue Specificity: Ubiquitous

Product Specifications

Recombinant Human Cold-inducible RNA-binding protein (CIRBP) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-172aa, with N-terminal GST-tagged tag, molecular weight 50.2kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed

Subcellular Location

Nucleus, nucleoplasm; Cytoplasm

Tissue Specificity

Ubiquitous

Subunit

Interacts with EIF4G1. Associates with ribosomes

Gene: CIRBP  |  Organism: Homo sapiens  |  Synonyms: A18 hnRNP; Glycine-rich RNA-binding protein CIRP
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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